Complexity, Pattern Formation and Chaos in the heart; a combined experimental and applied math approach for the study of arrhythmias."

Dynamical Systems Working Seminar
Tuesday, February 26, 2013 - 16:30
1 hour (actually 50 minutes)
Skiles 06
Georgia Tech (Physics)
The heart is an electro-mechanical system in which, under normal conditions, electrical waves propagate in a coordinated manner to initiate an efficient contraction. In pathologic states, propagation can destabilize and exhibit period-doubling bifurcations that can result in both quasiperiodic and spatiotemporally chaotic oscillations. In turn, these oscillations can lead to single or multiple rapidly rotating spiral or scroll waves that generate complex spatiotemporal patterns of activation that inhibit contraction and can be lethal if untreated. Despite much study, little is known about the actual mechanisms that initiate, perpetuate, and terminate reentrant waves in cardiac tissue. In this talk, I will discuss experimental and theoretical approaches to understanding the dynamics of cardiac arrhythmias. Then I will show how state-of-the-art voltage-sensitive fluorescent dyes can be used to image the electrical waves present in cardiac tissue, leading to new insights about their underlying dynamics. I will establish a relationship between the response of cardiac tissue to an electric field and the spatial distribution of heterogeneities in the scale-free coronary vascular structure. I will discuss how in response to a pulsed electric field E, these heterogeneities serve as nucleation sites for the generation of intramural electrical waves with a source density ?(E) and a characteristic time constant ? for tissue excitation that obeys a power law. These intramural wave sources permit targeting of electrical turbulence near the cores of the vortices of electrical activity that drive complex fibrillatory dynamics. Therefore, rapid synchronization of cardiac tissue and termination of fibrillation can be achieved with a series of low-energy pulses. I will finish with results showing the efficacy and clinical application of this novel low energy mechanism in vitro and in vivo. e